What does this research mean for the field?

Chronic antioxidant intervention in early renovascular disease improves renal hemodynamic responses and attenuates structural injury more effectively than acute intervention. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 6, 2004AJP Renal Physiology

Comparison of acute and chronic antioxidant interventions in experimental renovascular disease

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Why the study?

Does chronic antioxidant intervention improve renal hemodynamics and function more effectively than acute intervention in experimental renovascular disease?

Population

Pigs with simulated renovascular disease induced by concurrent hypercholesterolemia and renal artery…

Comparison

Acute infusion with SOD-mimetic tempol OR… vs Untreated RVD and normal controls

Design

Preclinical

Follow-up

12 weeks

Authors

ACAlejandro ChadeVascular / Pulmonary Vascular JKJames D. KrierMayo Clinic MRMartin Rodriguez‐PorcelMayo Clinic

Discussion

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Implication

Chronic antioxidants may outperform acute agents for renal hemodynamics in experimental RVD; leaves open translation to human trials.

Structured PICO

Does chronic antioxidant intervention improve renal hemodynamics and function more effectively than acute intervention in experimental renovascular disease?

Population

Pigs with simulated renovascular disease (RVD) induced by concurrent hypercholesterolemia and renal artery stenosis for 12 weeks (n=28 total: 7 RVD, 7 RVD+tempol, 7 RVD+vitamins, 7 normal control)

Intervention

Acute infusion with SOD-mimetic tempol OR chronic supplementation with antioxidant vitamins C (1 g) and E (100 IU/kg)

Comparator

Untreated RVD and normal controls

Outcome

Renal hemodynamics and function (basal renal blood flow, glomerular filtration rate, and ACh-stimulated renal blood flow)surrogate

Chronic antioxidant intervention with vitamins C and E improved renal hemodynamic responses more effectively than acute intervention with tempol in a pig model of renovascular disease, likely by decreasing structural injury and increasing nitric oxide bioavailability.

Cite This Study

Chade et al. (2004) studied this question.

synapsesocial.com/papers/6a1aa5b349c6765e3885bf8f https://doi.org/10.1152/ajprenal.00385.2003

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Comparison of acute and chronic antioxidant interventions in experimental renovascular disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparison of acute and chronic antioxidant interventions in experimental renovascular disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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