Key result
Diabetes was associated with a significantly increased risk of incident heart failure (IRR 2.36), ischaemic heart disease (IRR 1.66), and atrial fibrillation (IRR 1.17) compared to no diabetes.
Why the study?
The epidemiology of cardiovascular diseases in diabetes is evolving with changes in obesity-related conditions and preventive measures, necessitating updated population-based incidence studies.
Does diabetes increase the incidence of atrial fibrillation, ischaemic heart disease, and heart failure in a primary care population?
Cohort (n=142,311)
Yes
Does diabetes increase the incidence of atrial fibrillation, ischaemic heart disease, and heart failure in a primary care population?
Diabetes is associated with a significantly increased incidence of major chronic progressive heart diseases, particularly heart failure, which has a more than twofold increased risk compared to individuals without diabetes.
Answers are grounded in this paper and cite their sources.
May support closer monitoring for heart failure in diabetes; extends associations to a large primary care cohort but leaves causality open.
BACKGROUND: Diabetes has strongly been linked to atrial fibrillation, ischaemic heart disease and heart failure. The epidemiology of these cardiovascular diseases is changing, however, due to changes in prevalence of obesity-related conditions and preventive measures. Recent population studies on incidence of atrial fibrillation, ischaemic heart disease and heart failure in patients with diabetes are needed. METHODS: A dynamic longitudinal cohort study was performed using primary care databases of the Julius General Practitioners' Network. Diabetes status was determined at baseline (1 January 2014 or upon entering the cohort) and participants were followed-up for atrial fibrillation, ischaemic heart disease and heart failure until 1 February 2019. Age and sex-specific incidence and incidence rate ratios were calculated. RESULTS: Mean follow-up was 4.2 years, 12,168 patients were included in the diabetes group, and 130,143 individuals in the background group. Incidence rate ratios, adjusted for age and sex, were 1.17 (95% confidence interval 1.06-1.30) for atrial fibrillation, 1.66 (1.55-1.83) for ischaemic heart disease, and 2.36 (2.10-2.64) for heart failure. Overall, incidence rate ratios were highest in the younger age categories, converging thereafter. CONCLUSION: There is a clear association between diabetes and incidence of the major chronic progressive heart diseases, notably with heart failure with a more than twice increased risk.
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Groenewegen et al. (2021) conducted a cohort in Diabetes (n=142,311). Diabetes vs. No diabetes was evaluated on Incidence of heart failure (IRR 2.36, 95% CI 2.10-2.64). Diabetes was associated with a significantly increased risk of incident heart failure (IRR 2.36), ischaemic heart disease (IRR 1.66), and atrial fibrillation (IRR 1.17) compared to no diabetes.
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