Key result
Postmortem examination 72 hours after biodegradable polymer-based sirolimus-eluting stent implantation for STEMI revealed CD163-positive macrophages in close proximity to the stent struts.
Why the study?
The vascular healing process after drug-eluting stent implantation is not fully elucidated, and little is known regarding the role of human macrophages on reperfusion of culprit coronary arteries in patients with acute coronary syndrome.
Case Report (n=1)
This case report demonstrates the early accumulation of CD163-positive macrophages near stent struts 72 hours after sirolimus-eluting stent implantation in a STEMI patient.
Early CD163+ macrophage presence near struts in one STEMI case; hypothesis-generating for peristrut inflammation dynamics.
While the vascular healing process after drug-eluting stent implantation is not fully elucidated, it is generally accepted that macrophages play an important role in inflammation. It is also known that macrophages involved in the pathogenesis of atherosclerosis may stem from several origins, that is, monocyte-derived macrophages versus resident macrophages. However, little is known about the role of human macrophages on reperfusion of culprit coronary arteries in patients with atherosclerotic disease who have sustained acute coronary syndrome. In this present case report, we describe the presence of cluster of differentiation (CD) 163-positive macrophages in close proximity to the stent struts at the luminal site 72 hours after drug-eluting stent implantation in the culprit coronary lesion for ST elevation myocardial infarction by postmortem examination.
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Nakano et al. (2022) conducted a case report in ST elevation myocardial infarction (n=1). Biodegradable polymer-based sirolimus-eluting stent was evaluated on Presence of macrophages by postmortem examination. Postmortem examination 72 hours after biodegradable polymer-based sirolimus-eluting stent implantation for STEMI revealed CD163-positive macrophages in close proximity to the stent struts.
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