Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects, while FABP4 inhibition abrogates excess fatty acid accumulation in skeletal muscle.
Absolute Event Rate: 0% vs 0%
mice was associated with excess FA accumulation in the skeletal muscle. Treatment of these mice with an FABP4 inhibitor abrogated these metabolic phenotypes. These findings provide mechanistic insights that could greatly expand the therapeutic repertoire for type 2 diabetes and related metabolic disorders.
Hwangbo et al. (Wed,) reported a other. Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects, while FABP4 inhibition abrogates excess fatty acid accumulation in skeletal muscle.
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