Key result
Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects, while FABP4 inhibition abrogates excess fatty acid accumulation in skeletal muscle.
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Cautions against clinical use of APLNR or FABP4 modulators; leaves open their role in human cardiometabolic disease.
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Hwangbo et al. (2017) studied this question. Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects, while FABP4 inhibition abrogates excess fatty acid accumulation in skeletal muscle.
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