Key result
Young mice show no difference in post-MI strain changes versus old mice despite reduced EF.
Why the study?
This study aimed to compare changes in functional and strain parameters in young and old mice using cardiac MRI before and shortly after myocardial infarction.
Do changes in myocardial functional and strain parameters differ between young and old mice shortly after acute myocardial infarction?
Do changes in myocardial functional and strain parameters differ between young and old mice shortly after acute myocardial infarction?
In a mouse model of acute myocardial infarction, baseline differences in ventricular volumes exist between young and old mice, but acute post-infarction changes in strain parameters are similar across age groups.
Acute post-MI strain changes similar across mouse ages; leaves open translation to human remodeling and age effects.
Background/Objectives: This study aimed to compare changes in functional and strain parameters in young and old mice using cardiac MRI before and shortly after myocardial infarction. Methods: In this prospective experimental study, 7 young mice and 10 old mice underwent a cardiac MRI 5 days before and 2 days after myocardial infarction by LAD ligation. Functional parameters such as EDV, ESV, EF, SV, and Strain were determined. Results: EDV in the young mice before LAD ligation was significantly lower than in the old mice (p-value 0.002). EDV significantly increased after infarction in both groups. ESV was significantly lower in young mice before infarction than in old mice (9.7 ± 2.6 vs. 13.8 ± 3.9 [µL], p = 0.029). After infarction, the mean value was still lower but no longer significant. There was no significant difference between young and old mice either before or after infarction for the EF. But again, the decrease was significant for both groups (old: p < 0.0001 and young: p = 0.0009). Each global strain showed deterioration after infarction. This difference was significant in both subgroups for young mice and old mice for each strain. There were no differences either before or after infarction between the young and old mice. Conclusions: There were differences in functional parameters between young and old mice in EDV, SV, and CO. Changes in strain parameters in the acute phase post-myocardial infarction did not differ significantly between young and old mice, while there was a clear deterioration in strain parameters after infarction in both groups.
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Dalmer et al. (2025) studied Acute Myocardial Infarction (n=17). Young age (vs Old age) during LAD ligation vs. Old mice was evaluated on Changes in functional and strain parameters (EDV, ESV, EF, SV, and Strain). Young mice showed no significant differences in strain changes compared to old mice after myocardial infarction, though ejection fraction significantly decreased in both (p=0.0009 vs p<0.0001).
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