Key result
Captopril significantly reduced mortality in 14-month-old mice after myocardial infarction compared to untreated older mice (27.3% vs 64.0%, P<0.02).
Why the study?
Does captopril improve survival and cardiac function in a middle-aged mouse model of post-myocardial infarction heart failure?
Population
Male 14-month-old C57BL/6N mice and 2-month-old mice subjected to left coronary artery ligation to produce…
Comparison
Captopril (50 mg/kg/day) vs Untreated older mice and untreated young mice
Design
Preclinical
Follow-up
8 weeks
Authors
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Captopril may improve survival in middle-aged post-MI mice; extends prior data to a clinically relevant model but leaves human translation open.
Does captopril improve survival and cardiac function in a middle-aged mouse model of post-myocardial infarction heart failure?
Absolute Event Rate: 27.3% vs 64%
p-value: p=<0.02
Middle-aged mice represent a more clinically relevant model for post-myocardial infarction heart failure than young mice, demonstrating higher mortality and greater infarct expansion that can be partially mitigated by captopril.
Gould et al. (2002) studied Post-myocardial infarction heart failure (n=57). Captopril vs. Untreated older mice was evaluated on Mortality (p=<0.02). Captopril significantly reduced mortality in 14-month-old mice after myocardial infarction compared to untreated older mice (27.3% vs 64.0%, P<0.02).
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