Key result
Rheumatoid arthritis linked to ~48% greater risk of incident aortic stenosis.
Why the study?
Although rheumatoid arthritis is associated with an increased risk of ischemic cardiovascular disease, the risk of aortic stenosis was unknown.
Does rheumatoid arthritis increase the risk of incident aortic stenosis and related outcomes in adult patients?
Cohort (n=712,338)
Yes
Does rheumatoid arthritis increase the risk of incident aortic stenosis and related outcomes in adult patients?
Effect estimate: AHR 1.48 (95% CI 1.41-1.55)
Absolute Event Rate: 3.97% vs 2.45%
Rheumatoid arthritis is independently associated with a 48% increased risk of developing aortic stenosis and a higher risk of subsequent aortic valve interventions and AS-related death.
No takes yet. Share an insight, caveat, or question.
May support closer aortic stenosis surveillance in rheumatoid arthritis; leaves open causal mechanisms and therapy effects.
Johnson et al. (2023) conducted a cohort in Rheumatoid Arthritis (n=712,338). Rheumatoid arthritis vs. Patients without rheumatoid arthritis was evaluated on Composite of inpatient or outpatient aortic stenosis diagnosis, aortic valve intervention, or AS-related death (AHR 1.48, 95% CI 1.41-1.55). Rheumatoid arthritis was associated with a 48% increased risk of developing composite aortic stenosis compared to matched patients without rheumatoid arthritis (AHR 1.48).
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