Why the study?
Heart failure is a growing global health problem, and BNP is a promising cardiac biomarker released in response to ventricular stretch that may aid in early and specific detection.
Are plasma BNP levels elevated in patients with stable chronic heart failure compared to controls, and do they correlate with age, gender, and LVEF?
Case-Control (n=90)
No
Are plasma BNP levels elevated in patients with stable chronic heart failure compared to controls, and do they correlate with age, gender, and LVEF?
This study aims to evaluate plasma BNP as a biomarker in stable chronic heart failure patients in an Indian cohort and its correlation with clinical factors.
Evaluation of plasma BNP in stable HF yields no quantitative data; leaves open its biomarker role and correlations in Indian cohorts.
Introduction: Heart failure (HF) is a major and growing public health problem among the global population. Cardiac biomarkers are a promising tool for the early and specific detection of heart failure. B-type natriuretic peptide (BNP) is one such cardiac biomarker released in response to ventricular myocyte stretch. Aim: The aim of the present study was to estimate the levels of plasma BNP in patients with stable chronic heart failure (CHF) and to compare them with controls. Further to correlate the relationship between plasma BNP levels and factors like age, gender and left ventricular ejection fraction (LVEF), in the two groups. Materials and methods: A case-control study conducted in Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, India consisting of 55 stable CHF patients on treatment and 35 controls. Serum creatinine was estimated adopting modified Jaffe's method. eGFR was calculated using the modification of diet in renal disease (MDRD) formula. Plasma BNP levels were measured by ELISA.
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Bi et al. (2019) conducted a case-control in stable chronic heart failure (n=90). Plasma BNP measurement vs. Controls was evaluated on Plasma BNP levels.
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