What question did this study set out to answer?

To review the clinical characteristics, diagnostic taxonomy, underlying pathophysiology, and evidence-based therapeutic options for adult patients with complex regional pain syndrome type I.

May 1, 2002AnesthesiologyOpen Access

Complex Regional Pain Syndrome I (Reflex Sympathetic Dystrophy)

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Authors

SRSrinivasa N. RajaJohns Hopkins University TGTheodore S. GrabowMayo Clinic

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Implication

Clinical review details diagnostic criteria and multimodal management for complex regional pain syndrome I in adults, emphasizing early multidisciplinary care to restore physical function.

Key Points

To review the clinical characteristics, diagnostic taxonomy, underlying pathophysiology, and evidence-based therapeutic options for adult patients with complex regional pain syndrome type I.
Synthesized observational evidence, consensus diagnostic criteria from the International Association for the Study of Pain, and clinical trials addressing CRPS type I.
Evaluated diagnostic testing paradigms, psychologic and autonomic mechanisms, and interventions spanning pharmacotherapy, nerve blocks, neuromodulation, and rehabilitation.
Characterized CRPS type I by a clinical triad of disproportionate sensory symptoms (allodynia, hyperalgesia), autonomic changes (vasomotor and sudomotor instability), and motor deficits, with a female-to-male predominance of 2.3–3:1.
Demonstrated that traditional sequential disease staging is not supported by cluster analysis, and sympathetic nervous system outflow maintains pain in only a specific subset of patients.
Showed that multidisciplinary care emphasizing functional physiotherapy desensitization, adjuvant medications such as bisphosphonates, and spinal cord stimulation provides symptomatic benefit in refractory cases.

Cite This Study

Raja et al. (2002) studied this question.

synapsesocial.com/papers/6a1ae366e916fa6dd3b91a74 https://doi.org/10.1097/00000542-200205000-00031

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Implication

Clinical review details diagnostic criteria and multimodal management for complex regional pain syndrome I in adults, emphasizing early multidisciplinary care to restore physical function.

Complex Regional Pain Syndrome I (Reflex Sympathetic Dystrophy)

Discussion

Member takes

Implication

Key Points

Cite This Study

Complex Regional Pain Syndrome I (Reflex Sympathetic Dystrophy)

Discussion

Member takes

Implication

Key Points

Cite This Study

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