Key result
Obesity and hypertension independently attenuated endothelium-dependent vasodilation, with the lowest forearm blood flow response in obese hypertensive patients (10.4 vs 40.5 mL/min/100 mL; P<.001).
Why the study?
Do obesity and hypertension independently and interdependently impair endothelium-dependent vasodilation?
Observational (n=61)
Do obesity and hypertension independently and interdependently impair endothelium-dependent vasodilation?
Absolute Event Rate: 10.4% vs 40.5%
p-value: p=<.001
Obesity and hypertension are independently associated with impaired endothelium-dependent vasodilation, suggesting a synergistic negative effect on endothelial function.
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May support combined vascular risk assessment in obese hypertensives; leaves open causal and therapeutic implications.
Yukihito Higashi (2001) conducted an observational in Essential hypertension and obesity (n=61). Obesity and hypertension vs. Lean normotensive individuals was evaluated on Forearm blood flow (FBF) response to acetylcholine (p=<.001). Obesity and hypertension independently attenuated endothelium-dependent vasodilation, with the lowest forearm blood flow response in obese hypertensive patients (10.4 vs 40.5 mL/min/100 mL; P<.001).
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