Why the study?
Does infusion of glucose, insulin, and potassium increase the threshold for ventricular fibrillation in the nonischemic canine myocardium?
Does infusion of glucose, insulin, and potassium increase the threshold for ventricular fibrillation in the nonischemic canine myocardium?
GIK infusion increases the electrical threshold required to induce ventricular fibrillation in a nonischemic canine model, suggesting a potential protective antiarrhythmic effect.
GIK raises VF threshold in nonischemic canine myocardium; hypothesis-generating for antiarrhythmic effects and requires human trials.
We studied the influence of glucose (G), insulin (I) and potassium (K + ) on vulnerability to ventricular fibrillation (VF) of the nonischemic canine myocardium. Vulnerability was assessed by determining VF and repetitive extrasystole (RE) thresholds with a single stimulus applied to the right ventricular endocardium during the vulnerable period. Electrical testing of the heart was performed before and after 1 and 2 hours of infusing G (10 mg/kg per min) and I (0.025 U/kg per min) with and without K + . Infusion of glucose, insulin, and potassium (GIK) in 11 dogs significantly increased both VF (22%) and RE (33%) thresholds within the 1st hour and only the VF threshold (64%) in the 2nd hour.
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Obeid et al. (1978) studied this question.
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