Key result
Application of G-I-K solution, Xylocaine, and Dilantin significantly elevated the ventricular fibrillation threshold, which had fallen to 30% of control levels following experimental coronary ligation.
Why the study?
Does administration of G-I-K solution, lidocaine, or phenytoin improve the ventricular fibrillation threshold in a canine model of acute myocardial infarction?
Population
81 dogs with experimental acute myocardial infarction induced by occlusion of the anterior descending branch…
Comparison
G-I-K solution, lidocaine, and phenytoin vs Control
Design
Preclinical
Authors
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May support VF protection in acute ischemia models; hypothesis-generating and should not yet change practice.
Does administration of G-I-K solution, lidocaine, or phenytoin improve the ventricular fibrillation threshold in a canine model of acute myocardial infarction?
In a canine model of acute myocardial infarction, G-I-K solution, lidocaine, and phenytoin significantly elevated the ventricular fibrillation threshold, suggesting a protective effect against ventricular fibrillation.
Yukio Shinohara (1968) studied Acute myocardial infarction (experimental) (n=81). G-I-K solution, Xylocaine, and Dilantin vs. Control levels (post-ligation without agents) was evaluated on Ventricular fibrillation threshold (VFRT). Application of G-I-K solution, Xylocaine, and Dilantin significantly elevated the ventricular fibrillation threshold, which had fallen to 30% of control levels following experimental coronary ligation.
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