Key result
Significant CAD affects ~25% of LBBB patients and is linked to higher hypertension and diabetes.
Why the study?
Left bundle branch block has many causes, prompting evaluation of the true prevalence of CAD and associated hypertension and diabetes mellitus in these patients.
What is the prevalence of coronary artery disease in patients with left bundle branch block, and is it associated with hypertension and diabetes mellitus?
Cross-Sectional (n=400)
No
What is the prevalence of coronary artery disease in patients with left bundle branch block, and is it associated with hypertension and diabetes mellitus?
In patients with LBBB, ischemic causes are strongly associated with hypertension and diabetes, and a vast majority present with reduced ejection fraction.
Answers are grounded in this paper and cite their sources.
Prioritize CAD evaluation in LBBB patients with hypertension or diabetes; cross-sectional data leave open causal links.
Background: Left bundle branch block (LBBB) is a common finding in electrocardiography, there are many causes of LBBB. Objectives: The aim of this study is to discuss the true prevalence of coronary artery disease (CAD) in patients with LBBB and associated risk factors in the form of hypertension and diabetes mellitus. Materials and Methods: Patients with LBBB were admitted to the Iraqi heart center for cardiac disease in December 2017 to the end of April 2021; all patients underwent coronary angiography and they are classified into three groups: group 1: patients with proximal left anterior descending artery (LAD) or mid-LAD and either left circumflex artery (LCX) or right coronary artery (RCA) with lesion consider significant if more than 70% stenosis of the artery, group 2: patients with either isolated LCX or RCA with lesion if more than 70% stenosis of the artery, group 3: patients with normal coronary artery. Results: The most important finding in this study is that the percentage of LAD artery lesions or two vessels disease was only 24.5%. Patients in group 1 showed a high prevalence of hypertension (77.6%), whereas in group 3, the prevalence of hypertension was 47.95%. In this study, the prevalence of diabetes mellitus in group 1 was high (62.2%), whereas in group 3, it was 32%. Conclusion: High prevalence of men with LBBB than women, and the prevalence of LBBB increases with age. Patients who had hypertension and diabetes mellitus with LBBB most likely had an ischemic cause of LBBB, but patients with LBBB had low ejection fraction (EF) 369 out of 400 patients (90%) had low EF.
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Aljubawii et al. (2023) conducted a cross-sectional in Left bundle branch block (LBBB) (n=400). Significant LAD or two-vessel disease was found in 24.5% of LBBB patients, who had higher rates of hypertension (77.6% vs 48.0%) and diabetes (62.2% vs 32.0%) than those with normal coronaries.
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