Why the study?
Does intraoperative irrigated radiofrequency ablation (PVI or modified mini-maze) improve freedom from atrial fibrillation in patients with persistent atrial fibrillation undergoing CABG?
RCT (n=95)
Randomized
Does intraoperative irrigated radiofrequency ablation (PVI or modified mini-maze) improve freedom from atrial fibrillation in patients with persistent atrial fibrillation undergoing CABG?
Concomitant intraoperative radiofrequency ablation (PVI or modified mini-maze) during CABG substantially improves freedom from atrial fibrillation compared to CABG alone in patients with persistent AF.
Answers are grounded in this paper and cite their sources.
Supports concomitant ablation during CABG for persistent AF; extends RCT evidence for surgical AF ablation.
OBJECTIVES: We report our experience with a modified mini-maze procedure and pulmonary vein isolation using radiofrequency energy for treating persistent atrial fibrillation during coronary artery bypass grafting (CABG). METHODS: Ninety-five patients with persistent atrial fibrillation and coronary heart disease underwent open heart surgery combined with intraoperative irrigated radiofrequency ablation. Patients were randomized into the following three groups: CABG and irrigated radiofrequency pulmonary vein isolation (CABG+PVI, n = 31); CABG and an irrigated radiofrequency modified mini-maze procedure (CABG+MM, n = 30); and isolated CABG (CABG alone, n = 34). All patients received implantable loop recorders. RESULTS: No reoperation and no hospital mortality were recorded. Mean follow-up was 14.4 ± 9.7 months. The implantable loop recorder-determined freedom from atrial fibrillation was 80% in the CABG+PVI group, 86.2% in the CABG+MM group and 44.1% in the CABG alone group. CONCLUSIONS: Patients with concomitant atrial fibrillation and coronary heart disease may benefit from intraoperative ablation to prevent relapse of arrhythmia.
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Cherniavsky et al. (2014) conducted an RCT in Persistent atrial fibrillation and coronary heart disease (n=95). Intraoperative irrigated radiofrequency ablation (pulmonary vein isolation or modified mini-maze) vs. Isolated CABG was evaluated on Freedom from atrial fibrillation determined by implantable loop recorder.
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