Key result
Comorbid heart failure in new Alzheimer's patients linked to ~51% higher 1-year mortality.
Why the study?
Research on the influence of heart failure on mortality after Alzheimer's disease diagnosis was limited.
Does comorbid heart failure increase mortality in older adults aged 75 years and above newly diagnosed with Alzheimer's disease?
Cohort (n=32,363)
Does comorbid heart failure increase mortality in older adults aged 75 years and above newly diagnosed with Alzheimer's disease?
Comorbid heart failure significantly increases one-year mortality in older adults newly diagnosed with Alzheimer's disease, with a more pronounced effect in women than in men.
BACKGROUND: Research on the influence of heart failure on mortality after Alzheimer's disease diagnosis is limited. OBJECTIVE: To evaluate the association between comorbid heart failure and mortality following Alzheimer's disease diagnosis, particularly considering sex differences. METHODS: We analyzed administrative claims data from Japan, involving 32,363 individuals (11,064 men and 21,299 women) aged 75 or older newly diagnosed with Alzheimer's disease, with 7% having comorbid heart failure. Cox proportional hazard models and population attributable fractions (PAFs) were used to evaluate the association between comorbid heart failure and mortality within one year following Alzheimer's disease diagnosis. RESULTS: Individuals with Alzheimer's disease and heart failure had a multivariate-adjusted hazard ratio of 1.51 (95% confidence interval [CI], 1.32-1.73) for mortality during the one-year follow-up period compared to those with Alzheimer's disease and without heart failure. Subgroup analysis by sex revealed a higher mortality hazard ratio in women of 1.63 (95% CI, 1.36-1.95) than that in men of 1.39 (95% CI, 1.13-1.71). Further age and sex subgroup analysis indicated that women across all age brackets-75-79, 80-84, and ≥ 85 years-had higher mortality hazard ratios. The PAF for heart failure increased with age in both sexes, with women having higher PAFs than men, and the sex difference in PAF being most pronounced in the 75-79 age category (men: 1.4%, women: 4.0%). CONCLUSIONS: Hazard ratios and PAFs for mortality associated with comorbid heart failure in newly diagnosed Alzheimer's disease are higher in women than in men, which persists across all age subgroups.
No takes yet. Share an insight, caveat, or question.
Matsunaga et al. (2025) conducted a cohort in Alzheimer's disease (n=32,363). Comorbid heart failure vs. Without heart failure was evaluated on Mortality within one year following Alzheimer's disease diagnosis (HR 1.51, 95% CI 1.32-1.73). Comorbid heart failure in older adults newly diagnosed with Alzheimer's disease was associated with increased 1-year mortality (HR 1.51; 95% CI 1.32-1.73), with a higher risk observed in women.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: