Studies on Digitalis. I. Direct Effects on Peripheral Vascular Resistance
Why the study?
Do digitalis glycosides directly affect peripheral vascular resistance in dogs?
Population
Dog model
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Should not alter digitalis use in patients; leaves open translation of direct vascular effects to human disease.
Key Points
- The aim is to characterize the direct effects of digitalis glycosides on peripheral vascular resistance, excluding cardiac influences.
- Conducted on dogs using two types of digitalis preparations.
- Eliminated the circulatory effects resulting from the positive inotropic action of the drugs.
- Defined the direct influence of digitalis on peripheral vascular resistance in a controlled environment.
- Observed significant alterations in vascular dynamics attributable to digitalis.
Structured PICO
Do digitalis glycosides directly affect peripheral vascular resistance in dogs?
P
Population
Dog model (two types of preparations employed to eliminate circulatory effects resulting from inotropic action)
I
Intervention
Several digitalis glycosides
O
Outcome
Direct effects on peripheral vascular resistancesurrogate
This preclinical study aimed to characterize the direct effects of digitalis glycosides on peripheral vascular resistance independent of their cardiac inotropic effects.
Cite This Study
Ross et al. (1960) studied this question.