Key result
In hypertensive patients with preserved LVEF, 2 weeks of bisoprolol treatment decreased global longitudinal strain and strain rate (P<0.05) while increasing circumferential contractility.
Why the study?
Does short-term treatment with bisoprolol alter components of left ventricular mechanics in hypertensive outpatients with normal LVEF?
Population
26 hypertensive outpatients without previous cardiovascular events and with normal left ventricular ejection…
Comparison
Bisoprolol for 2 weeks vs Baseline (before treatment)
Design
Cohort
Follow-up
2 weeks
Authors
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Short-term bisoprolol may alter LV strain components differently in hypertensive patients with preserved LVEF; leaves open whether longitudinal parameters should guide therapy or monitoring.
Observational (n=26)
Does short-term treatment with bisoprolol alter components of left ventricular mechanics in hypertensive outpatients with normal LVEF?
p-value: p=<0.05
In hypertensive patients with preserved LVEF, short-term beta-1 blockade with bisoprolol decreases longitudinal strain but increases circumferential contractility, suggesting longitudinal parameters may not accurately reflect overall myocardial contractility status.
Palmieri et al. (2009) conducted an observational in Hypertension (n=26). Bisoprolol vs. Baseline was evaluated on Change in left ventricular systolic mechanics (circumferential and longitudinal contractility, strain, and strain rate) (p=<0.05). In hypertensive patients with preserved LVEF, 2 weeks of bisoprolol treatment decreased global longitudinal strain and strain rate (P<0.05) while increasing circumferential contractility.
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