Key result
Ouabain induced a higher incidence of delayed afterdepolarizations (80% vs 30%, P<0.05) and spontaneous activity (60% vs 10%, P<0.05) in young rabbit left atrial posterior walls than appendages.
Why the study?
Does aging and ouabain administration affect left atrial electrophysiological heterogeneity and arrhythmogenicity in rabbit tissue?
Population
Isolated young and aged rabbit left atrial posterior wall and left atrial appendage tissue specimens
Comparison
Ouabain (1 microM) administration vs Baseline and comparison between young and aged…
Design
Preclinical
Authors
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Animal findings on regional ouabain arrhythmogenicity in young rabbits require cautious interpretation; leaves open aging effects on atrial vulnerability.
Does aging and ouabain administration affect left atrial electrophysiological heterogeneity and arrhythmogenicity in rabbit tissue?
Absolute Event Rate: 80% vs 30%
p-value: p=<0.05
Aging enhances left atrial regional electrical heterogeneity and posterior wall arrhythmogenesis, providing a mechanistic basis for increased atrial fibrillation vulnerability in older age.
Wongcharoen et al. (2007) studied Atrial fibrillation vulnerability (n=19). Ouabain vs. Left atrial appendage (LAA) / Young tissue was evaluated on Incidence of delayed afterdepolarizations (DADs) in young LAPWs vs young LAAs (p=<0.05). Ouabain induced a higher incidence of delayed afterdepolarizations (80% vs 30%, P<0.05) and spontaneous activity (60% vs 10%, P<0.05) in young rabbit left atrial posterior walls than appendages.
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