Key result
Noninvasive assessment using LDF and c-PPG revealed significantly reduced endothelial activity in both upper and lower extremities of PAD patients compared to normal patients over age 50.
Why the study?
Does noninvasive assessment of endothelial activity using LDF and c-PPG detect systemic endothelial dysfunction in patients with PAD compared to normal subjects?
Observational (n=130)
Does noninvasive assessment of endothelial activity using LDF and c-PPG detect systemic endothelial dysfunction in patients with PAD compared to normal subjects?
Noninvasive assessment of endothelial activity using LDF and c-PPG demonstrates systemic endothelial dysfunction in patients with PAD compared to normal older adults.
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Supports detection of systemic endothelial dysfunction in PAD via LDF/c-PPG; hypothesis-generating and requires validation before clinical use.
Fronek et al. (2007) conducted an observational in Peripheral arterial disease (n=130). Laser Doppler fluxmetery (LDF) and calibrated photoplethysmography (c-PPG) after acetylcholine iontophoresis vs. Non-PAD subjects was evaluated on Microvascular endothelial activity (EA) assessed by integrated area under response curve. Noninvasive assessment using LDF and c-PPG revealed significantly reduced endothelial activity in both upper and lower extremities of PAD patients compared to normal patients over age 50.
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