Key result
Irrigation of post-appendectomy wounds with 1% povidone-iodine solution significantly reduced the frequency of surgical site infections compared to no irrigation (31.6% vs 35.0%, p<0.05).
Why the study?
The study evaluated the efficacy of postoperative povidone-iodine prophylaxis on surgical site infection in appendectomy surgery.
Does 1% povidone-iodine solution reduce surgical site infection in patients undergoing appendectomy for acute appendicitis?
RCT (n=120)
Open-label
Randomized into 2 groups
No
Does 1% povidone-iodine solution reduce surgical site infection in patients undergoing appendectomy for acute appendicitis?
Absolute Event Rate: 31.6% vs 35%
p-value: p=<0.05
Prophylactic application of 1% povidone-iodine to the subcutaneous tissue before skin closure in appendectomy may improve normal wound healing and reduce surgical site infections.
Supports povidone-iodine irrigation to reduce SSIs after appendectomy; confirms benefit in this RCT.
Objectives: Efficacy of postoperative Povidone-Iodine prophylaxis and surgical site infection in appendectomy surgery. Study Design: Randomized clinical trial. Place and Duration: Department of Surgery, Liaquat University Hospital Jamshoro/Hyderabad from March 2016 to November 2017. Subjects and Methods: Diagnosed cases of acute appendicitis with classical clinical presentation were included in the study protocol. 60 patients were those, who were applied 1% povidone-iodine solution (cases) to wound post operatively versus 60 patients (control) were those in whom wound not irrigated with Povidone- Iodine. Ethical approval and consent were taken. Data was noted in a proforma and analyzed on SPSS 22.0 (P≤0.05). Results: Age (mean ± SD) in control and cases was observed as 25.5 ± 8.5 and 24.5 ± 9.5 years respectively (P=0.76). Male and female were noted as 43 (%) and 17 (%) & 45 (%) and 15 (%) in control and cases respectively (P >0.05). Wound healing score by Southampton classification of wound healing shows lesser frequency of surgical site infection in cases compared to controls (P <0.05). Grade 4 pus discharging wound infection was noted in 2 (3.33%) control versus 3 (5.0%) in cases (P=0.021). Conclusion: It is concluded that the 1% Povidone- Iodine solution is effective in preventing the post appendectomy surgical site infection.
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Memon et al. (2019) conducted an RCT in Acute appendicitis (n=120). 1% Povidone-Iodine solution vs. No Povidone-Iodine application was evaluated on Surgical site infection (Southampton wound grades 1-4) (p=<0.05). Irrigation of post-appendectomy wounds with 1% povidone-iodine solution significantly reduced the frequency of surgical site infections compared to no irrigation (31.6% vs 35.0%, p<0.05).
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