Why the study?
Does dipyridamole/acetylsalicylic acid or low-dose subcutaneous heparin prevent postoperative deep vein thrombosis in high-risk patients?
Does dipyridamole/acetylsalicylic acid or low-dose subcutaneous heparin prevent postoperative deep vein thrombosis in high-risk patients?
Low-dose subcutaneous heparin significantly reduces the incidence of postoperative deep vein thrombosis in high-risk patients compared to control or antiplatelet therapy, without increasing bleeding complications.
Low-dose heparin prophylaxis merits use in high-risk postoperative patients; confirms superiority over antiplatelet therapy for DVT prevention.
In a prospective randomised trial, three groups of 20 patients each were compared. A first group served as a control, a second group received dipyridamole and acetylsalicylic acid and a third group received low doses of heparin. The incidence of deep vein thrombosis determined by the 125I-fibrinogen test was 40% in the first group, 50% in the second group, and 5% in the third group. The differences between the heparin group and the two other groups are statistically significant. No wound complication and no haematoma at the injection site occurred.
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Dechavanne et al. (2009) studied this question.
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