Key result
A single pre-operative low dose of heparin did not reduce the incidence of post-operative deep-vein thrombosis compared to placebo (14.5% vs 12.3%).
Why the study?
Does a single pre-operative low dose of heparin prevent post-operative deep-vein thrombosis in surgical patients?
RCT (n=112)
Double-blind
randomly allocated
Does a single pre-operative low dose of heparin prevent post-operative deep-vein thrombosis in surgical patients?
Absolute Event Rate: 14.5% vs 12.3%
A single pre-operative low dose of heparin does not reduce the incidence of post-operative deep-vein thrombosis compared to placebo.
Single pre-operative low-dose heparin does not prevent post-operative DVT; confirms ineffectiveness of this regimen and supports alternative prophylaxis strategies.
Summary A consecutive, randomly allocated, controlled, double-blind clinical trial of the prophylactic effect of a single pre-operative low dose of heparin on the incidence o-post-operative deep-vein thrombosis showed no reducf tion in the number of thromboses detected. Fifty-five patients were given 5000 units of heparin subcutaneously 1-1½ hr pre-operatively and fifty-seven patients were given a placebo. The incidence of thrombosis detected by the doppler ultrasound was 14·5% in the heparin group and 12·3% in the control group. It is suggested that a further trial monitored by ultrasound is indicated in which low-dose heparin is given for various periods post-operatively in addition to a pre-operative dose.
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T Bates (1974) conducted an RCT in post-operative deep-vein thrombosis (n=112). heparin vs. placebo was evaluated on incidence of post-operative deep-vein thrombosis detected by doppler ultrasound. A single pre-operative low dose of heparin did not reduce the incidence of post-operative deep-vein thrombosis compared to placebo (14.5% vs 12.3%).
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