Why the study?
Does the combination of dipyridamole and aspirin prevent postoperative deep vein thrombosis in patients undergoing operation?
Does the combination of dipyridamole and aspirin prevent postoperative deep vein thrombosis in patients undergoing operation?
The combination of dipyridamole and aspirin administered perioperatively reduces the incidence of postoperative deep vein thrombosis.
Answers are grounded in this paper and cite their sources.
May lower postoperative DVT with perioperative dipyridamole-aspirin; leaves open need for randomized confirmation before practice change.
One hundred and sixty patients have been studied in a controlled trial of two drugs which have been in combination to prevent postoperative-deep-vein thrombosis. Both the drugs, dipyridamole (Persantin) and aspirin, were given by mouth from the evening before operation and for seven days after operation. The radioactive fibrinogen test was used to diagnose thrombosis. Of the 85 patients in the control group 24 developed thrombosis (28%). Twelve out of 85 patients (14%) in the test group were found to have thrombosis. Similar significant differences in incidence were found in the various subgroups.
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Renney et al. (1976) studied this question.
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