Key result
Microbubble sonothrombolysis improves ST-segment resolution and vessel recanalization versus standard care in STEMI.
Why the study?
Current standard STEMI treatments have limitations, prompting review of the clinical application of sonothrombolysis as an adjuvant therapy modality based on evidence from the last ten years.
Does sonothrombolysis as an adjunct to PCI improve ST-segment resolution and vessel recanalization rates in patients with STEMI?
Systematic Review (n=887)
Does sonothrombolysis as an adjunct to PCI improve ST-segment resolution and vessel recanalization rates in patients with STEMI?
Sonothrombolysis with microbubble infusion as an adjunct to PCI appears to be a safe and effective strategy to improve ST-segment resolution and vessel recanalization in patients with STEMI.
Current standard ST-segment elevation myocardial infarction (STEMI) treatments, such as percutaneous coronary intervention (PCI) and thrombolytic agent administration, still have some limitations. Sonothrombolysis is a new therapeutic modality that utilizes ultrasound energy to break up thrombus and is currently considered a promising alternative therapeutic strategy to treat STEMI. This systematic review aims to further review the clinical application of sonothrombolysis as an adjuvant therapy modality in STEMI based on the evidence available in the last ten years. We systematically searched studies on PubMed, Cochrane Library, and ScienceDirect databases. After removing duplicates and screening studies based on inclusion and exclusion criteria, data extraction and critical appraisal were performed by three independent reviewers. Study search and selection resulted in five studies with 614 patients and an additional 273 patients as a reference group. Results showed that patients treated with an intermittent, short pulse, and high mechanical index sonothrombolysis with microbubble infusion had significantly better ST-segment resolution and vessel recanalization rates than the other treatment groups. In addition, there was no significant difference in the safety level among all intervention groups. In conclusion, sonotrombolysis is a promising novel therapy that is an adjunct to PCI, which is effective and safe for treating STEMI.
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Rayyan et al. (2023) conducted a systematic review in ST-elevation myocardial infarction (STEMI) (n=887). Sonothrombolysis with microbubble infusion vs. Other treatment groups was evaluated on ST-segment resolution and vessel recanalization rates. Sonothrombolysis with microbubble infusion significantly improved ST-segment resolution and vessel recanalization rates compared to other treatments across 5 studies including 887 STEMI patients.
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