Key result
Therapeutic ultrasound enhances thrombolysis by micromechanical processes or indirectly by supporting enzymatic thrombolysis in patients with acute myocardial infarction.
Therapeutic ultrasound may enhance enzymatic thrombolysis in patients with ST-elevation myocardial infarction through micromechanical processes.
Should not yet alter thrombolysis protocols in AMI; hypothesis-generating and requires prospective RCTs for confirmation.
Thrombolytic therapy is widely used to treat the patients with ST elevation acute myocardial infarction (STE-MI). Due to logistic and economic reasons, only 10% of patients with acute myocardial infarction can be treated with the percutaneous coronary intervention (PCI). Optimal flow (TIMI (Thrombolysis In Myocardial Infarction) 3 flow) is achieved in only about 60% of cases by enzymatic thrombolysis. Therapeutic ultrasound (US) exerts an effect on thrombolysis by micromechanical processes or indirectly by supporting enzymatic thrombolysis. This review examines relevant experimental and clinical published data. Technical issues in therapeutic US-enhanced thrombolysis in patients with acute myocardial infarction and advancements of the techniques during recent 10 years are discussed.
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Shen et al. (2009) conducted a review in ST elevation acute myocardial infarction (STE-MI). Therapeutic ultrasound-enhanced thrombolysis was evaluated. Therapeutic ultrasound enhances thrombolysis by micromechanical processes or indirectly by supporting enzymatic thrombolysis in patients with acute myocardial infarction.
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