Key result
Vagus nerve stimulation is an attractive device-based therapy for modulating autonomic nervous system dysfunction in patients with heart failure.
Why the study?
Autonomic imbalance contributes to heart failure progression, making autonomic nervous system modulation by device-based therapy an attractive treatment target.
This review summarizes the role of autonomic nervous system dysfunction in heart failure and the available evidence for vagus nerve stimulation as a device-based therapy.
Answers are grounded in this paper and cite their sources.
Caution against routine clinical use in HF; leaves open need for definitive RCTs on vagus nerve stimulation.
Heart failure (HF) is one of the most prevalent cardiovascular diseases and is associated with high morbidity and mortality. Mechanistically, HF is characterized by an overactive sympathetic nervous system and parasympathetic withdrawal, and this autonomic imbalance contributes to the progression of the disease. As such, modulation of autonomic nervous system by device-based therapy is an attractive treatment target. In this review, we discuss the role of autonomic nervous system dysfunction in the pathogenesis of HF and present the available evidence regarding vagus nerve stimulation for HF, with special emphasis on optimization of stimulation parameters. Finally, we discuss future avenues of research for neuromodulation in patients with HF.
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Asad et al. (2019) conducted a review in Heart failure. Vagus nerve stimulation was evaluated. Vagus nerve stimulation is an attractive device-based therapy for modulating autonomic nervous system dysfunction in patients with heart failure.
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