What does this research mean for the field?

Hypertension is a major risk factor for the development of severe white matter hyperintensities, and achieving normal blood pressure through antihypertensive medication significantly reduces this risk. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To explore the link between baseline hypertension and white matter hyperintensities severity at a 4-year follow-up.

April 10, 2001Neurology

Longitudinal study of blood pressure and white matter hyperintensities

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Why the study?

Does baseline hypertension increase the risk of severe white matter hyperintensities on MRI in older adults?

Population

845 subjects aged 59 to 71 years old at entry from the Epidemiology of Vascular Ageing study

Comparison

Baseline hypertension vs Normal blood pressure or controlled blood…

Design

Cohort

Follow-up

4 years

Authors

CDCarole DufouilUniversité de Bordeaux AKA. De Kersaint-GillyCentre Hospitalier Universitaire de Nantes VBVéronique BesançonCentre National de la Recherche Scientifique

Discussion

Member takes

Implication

May support BP control to mitigate severe WMH risk in older adults; leaves open need for RCTs to confirm causality.

Key Points

To explore the link between baseline hypertension and white matter hyperintensities severity at a 4-year follow-up.
Longitudinal study of 845 subjects aged 59 to 71 from the Epidemiology of Vascular Ageing study.
Magnetic Resonance Imaging (MRI) used to assess WMH severity at a 4-year follow-up.
Hypertension defined as systolic BP >=160 mm Hg, diastolic BP >=95 mm Hg, or use of antihypertensive medication.
Baseline hypertension linked to higher risk of severe WMH at follow-up.
Risk of severe WMH was lower in subjects with controlled blood pressure on antihypertensive medication.
Higher frequency of severe WMH found in individuals hypertensive at both baseline and follow-up compared to those hypertensive only at follow-up.

Structured PICO

Does baseline hypertension increase the risk of severe white matter hyperintensities on MRI in older adults?

Population

845 subjects aged 59 to 71 years old at entry from the Epidemiology of Vascular Ageing study

Intervention

Baseline hypertension (systolic blood pressure ≥160 mm Hg, diastolic blood pressure ≥95 mm Hg, or use of antihypertensive medication)

Comparator

Normal blood pressure or controlled blood pressure on antihypertensive medication

Outcome

Severity of white matter hyperintensities (WMH) on cerebral MRI at 4-year follow-upsurrogate

Baseline hypertension is a major risk factor for severe white matter hyperintensities, but controlling blood pressure with medication reduces this risk.

Cite This Study

Dufouil et al. (2001) studied this question.

synapsesocial.com/papers/6a1ba4530ea968f653ac0f18 https://doi.org/10.1212/wnl.56.7.921

Topics

Hypertension management

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Longitudinal study of blood pressure and white matter hyperintensities

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Longitudinal study of blood pressure and white matter hyperintensities

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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