What does this research mean for the field?

In patients with severe aortic stenosis, myocardial fibrosis is the critical abnormality that differentiates an adaptive, physiologic left ventricular hypertrophy from a maladaptive, non-physiologic response to increased afterload. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to evaluate the impact of myocardial fibrosis on the type of left ventricular hypertrophy in patients with severe aortic stenosis.

January 1, 2011CardiologyOpen Access

Influence of Myocardial Fibrosis on Left Ventricular Hypertrophy in Patients with Symptomatic Severe Aortic Stenosis

View Full Paper

Ask AI

Bookmark

Why the study?

Does myocardial fibrosis correlate with maladaptive (non-physiologic) left ventricular hypertrophy in patients with symptomatic severe aortic stenosis?

Key Points

This study aims to evaluate the impact of myocardial fibrosis on the type of left ventricular hypertrophy in patients with severe aortic stenosis.
Evaluated myocardial fibrosis in 79 patients undergoing aortic valve replacement for symptomatic aortic stenosis.
Distinguished between physiologic and non-physiologic left ventricular hypertrophy using echocardiographic measurements of wall stress.
Follow-up assessments at 7.4 ± 2.1 months included left ventricular mass index and NYHA class.
Fibrosis tissue mass index was inversely related to LV fractional shortening and directly to LV diastolic and systolic diameter and LV mass index.
Patients with non-physiologic hypertrophy (n=24) exhibited higher LV mass index and impaired systolic and diastolic functions, with lower fractional shortening and higher mean wedge pressure.
At follow-up, LV mass index and NYHA class remained elevated in patients with non-physiologic hypertrophy.

Structured PICO

Does myocardial fibrosis correlate with maladaptive (non-physiologic) left ventricular hypertrophy in patients with symptomatic severe aortic stenosis?

Population

79 patients with symptomatic severe aortic stenosis undergoing aortic valve replacement

Intervention

Evaluation of myocardial fibrosis using specimens taken from the ventricular septum

Comparator

Physiologic LV hypertrophy (end-systolic wall stress <90 kdyn/cm2) vs non-physiologic hypertrophy (end-systolic wall stress >90 kdyn/cm2)

Outcome

Correlation between fibrosis tissue mass index and LV echocardiographic parameters (fractional shortening, diameters, LV mass index)surrogate

Myocardial fibrosis appears to be a critical abnormality that differentiates adaptive from maladaptive left ventricular hypertrophy in patients with severe aortic stenosis.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports fibrosis as marker of maladaptive LVH in severe AS; hypothesis-generating, requires prospective validation before practice change.

Cite This Study

Golia et al. (2011) studied this question.

synapsesocial.com/papers/6a1bc04cc97d63156a5edf09 https://doi.org/10.1159/000334792

Topics

Cardiomyopathy

View Full Paper

Ask AI

Bookmark

Implication

Supports fibrosis as marker of maladaptive LVH in severe AS; hypothesis-generating, requires prospective validation before practice change.

Influence of Myocardial Fibrosis on Left Ventricular Hypertrophy in Patients with Symptomatic Severe Aortic Stenosis

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Influence of Myocardial Fibrosis on Left Ventricular Hypertrophy in Patients with Symptomatic Severe Aortic Stenosis

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider