Key result
In patients with aortic valve disease, massive preoperative muscle fiber diameter (35 vs 30 mu; P<0.01) heralds unfavorable postoperative LV function, and interstitial fibrosis is irreversible.
Why the study?
Does aortic valve replacement reverse pathologic myocardial structure in patients with LV hypertrophy from aortic valve disease?
Population
Patients with moderate left ventricular (LV) hypertrophy from aortic valve disease
Comparison
Aortic valve replacement vs Compensated LV function versus left heart failure
Design
Cohort
Follow-up
17 months
Authors
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Massive preoperative fiber hypertrophy may flag high-risk AVR candidates for poor LV recovery; leaves open whether earlier intervention limits irreversible fibrosis.
Observational
Does aortic valve replacement reverse pathologic myocardial structure in patients with LV hypertrophy from aortic valve disease?
In secondary hypertrophy from aortic valve disease, myocardial structure is pathologic even with normal LV function, and massive fiber hypertrophy predicts unfavorable postoperative LV function while fibrosis remains irreversible after surgical correction.
Krayenbuehl et al. (1983) conducted an observational in Left ventricular hypertrophy from aortic valve disease. Aortic valve replacement vs. Compensated LV function vs left heart failure was evaluated on Interstitial fibrosis and muscle fiber diameter. In patients with aortic valve disease, massive preoperative muscle fiber diameter (35 vs 30 mu; P<0.01) heralds unfavorable postoperative LV function, and interstitial fibrosis is irreversible.
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