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August 30, 2017Frontiers in PhysiologyOpen Access

Increased Hemodynamic Load in Early Embryonic Stages Alters Myofibril and Mitochondrial Organization in the Myocardium

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Population

Chicken embryo hearts between Hamburger and Hamilton stages 18 and 24

Design

Preclinical

Follow-up

~ 24hrs during tubular heart stages

Authors

MMMadeline MidgettCLClàudia LópezLDLarry L. David

Discussion

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Overview

May link embryonic hemodynamic load to congenital malformations; hypothesis-generating for human cardiac development.

Structured PICO

P
Population
Chicken embryo hearts between Hamburger and Hamilton stages 18 and 24
I
Intervention
Outflow tract banding to increase hemodynamic load
O
Outcome
Myofibril and mitochondrial configuration in the outflow tract myocardium in vivosurrogate

Increased hemodynamic load in early embryonic stages alters myofibril and mitochondrial organization, which may contribute to cardiac malformations seen in congenital heart disease.

Cite This Study

Midgett et al. (2017) studied this question.

synapsesocial.com/papers/6a1bc295bc71fb1015a8ef0ehttps://doi.org/10.3389/fphys.2017.00631
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Also Consider

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  1. 1Blood flow dynamics reflect degree of outflow tract banding in Hamburger–Hamilton stage 18 chicken embryos2014 · 48 citations
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