Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 27, 2014Journal of The Royal Society InterfaceOpen Access

Blood flow dynamics reflect degree of outflow tract banding in Hamburger–Hamilton stage 18 chicken embryos

View Full Paper
Ask AI
Bookmark
Share

Population

Hamburger-Hamilton stage 18 chicken embryos (n=41)

Comparison

Heart outflow tract banding vs Control (unbanded) embryos

Design

Preclinical

Follow-up

immediate

Authors

MMMadeline MidgettOregon Health & Science UniversitySGSevan GoenezenWalker (United States)SRSandra RugonyiOregon Health & Science University

Discussion

Loading...

Member takes

Implication

Caution against extrapolating chick embryo banding responses to human congenital defects; leaves open shear-mediated mechanisms of early cardiac adaptation.

Structured PICO

P
Population
Hamburger-Hamilton stage 18 chicken embryos (n=41)
I
Intervention
Heart outflow tract banding (6-64% measured band tightness)
C
Comparator
Control (unbanded) embryos
O
Outcome
Immediate blood flow response (peak blood flow velocity, wall shear rate, time of flow, stroke volume) measured by optical coherence tomographysurrogate

In a chick embryo model, the early embryonic cardiovascular system shows immediate hemodynamic adaptations to increased load from outflow tract banding, maintaining stroke volume despite altered flow velocities and shear rates.

Cite This Study

Midgett et al. (2014) studied this question.

synapsesocial.com/papers/6a1bc298bc71fb1015a8ef14https://doi.org/10.1098/rsif.2014.0643

Topics

Congenital heart disease adults
View Full Paper
Ask AI
Bookmark
Share