Key result
Outflow tract constriction in embryonic chicken hearts increased ventricular mass by 64% at stage 29 with identical vascular volume density, but ultimately impeded main coronary artery formation.
Population
Hamburger-Hamilton stage 21 chicken hearts (prior to the onset of coronary vasculogenesis)
Comparison
Constriction of the outflow tract in ovo with a… vs Sham-operated controls
Design
Preclinical
Follow-up
Until Hamburger-Hamilton stages 29 and 36
Authors
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No immediate clinical implications for congenital heart disease; leaves open hemodynamic effects on coronary development in mammalian models.
In embryonic chicken hearts, vascular growth is proportional to myocardial growth during early pressure overload, but persistent overload impairs coronary artery development.
Robert J. Tomanek (1999) studied Embryonic chicken hearts. Outflow tract constriction (pressure overload) vs. Sham-operated controls was evaluated on Vascular volume density, numerical density, and coronary artery development. Outflow tract constriction in embryonic chicken hearts increased ventricular mass by 64% at stage 29 with identical vascular volume density, but ultimately impeded main coronary artery formation.
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