Key result
Venous obstruction by clipping significantly reduced end-systolic elastance (2.91 vs 7.53 mmHg/microL, P<0.005) and increased diastolic stiffness in stage-24 chicken embryos.
Why the study?
Does permanent obstruction of the right lateral vitelline vein alter intrinsic systolic and diastolic ventricular function in stage-24 chicken embryos?
Population
in-ovo stage-24 chicken embryos (n=30)
Comparison
Permanent obstruction of the right lateral… vs Control embryos
Design
Preclinical
Follow-up
2 days
Authors
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Embryonic venous obstruction impairs ventricular function; leaves open mechanistic role in human congenital heart disease.
Does permanent obstruction of the right lateral vitelline vein alter intrinsic systolic and diastolic ventricular function in stage-24 chicken embryos?
Absolute Event Rate: 2.91% vs 7.53%
p-value: p=<0.005
Venous obstruction in chicken embryos impairs intrinsic systolic and diastolic ventricular function, which may precede morphological derangements in cardiac development.
Vos et al. (2007) studied Cardiac development in chicken embryos (n=30). Venous obstruction by clipping the right lateral vitelline vein vs. Control embryos was evaluated on End-systolic elastance (slope of end-systolic pressure-volume relationship) (p=<0.005). Venous obstruction by clipping significantly reduced end-systolic elastance (2.91 vs 7.53 mmHg/microL, P<0.005) and increased diastolic stiffness in stage-24 chicken embryos.
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