Why the study?
Does acute conotruncal occlusion alter ventricular function in stage 21 chick embryos?
Population
Stage 21 chick embryos (n=35 total; n=15 in protocol 1, n=20 in protocol 2)
Comparison
Acute conotruncal (CT) ligation/occlusion vs Baseline recording (normal ejection)
Design
Preclinical
Authors
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Indicates masked contractile reserve in embryonic chick ventricle; leaves open translational relevance to human fetal function.
Does acute conotruncal occlusion alter ventricular function in stage 21 chick embryos?
The embryonic ventricle has significant contractile reserve that is masked in vivo by the dynamic coupling between the ventricle and arterial circulation.
Keller et al. (1997) studied this question.
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