January 1, 1994Cardiology in the Young

Embryonic ventricular diastolic and systolic pressure-volume relations

View Full Paper

Ask AI

Bookmark

Population

n≥6 stage 16, 18 and 21 white Leghorn chick embryos

Comparison

Infusion of 1-2 microliters of physiologic… vs Baseline

Design

Preclinical

Authors

BKBradley B. KellerCincinnati Children's Hospital Medical Center JTJoseph P. TinneyUniversity of Louisville NHNorman HuUniversity of Utah

Discussion

Member takes

Implication

Defines embryonic ventricular mechanics; leaves open translation to human fetal cardiology.

Structured PICO

Population

n≥6 stage 16, 18 and 21 white Leghorn chick embryos

Intervention

Infusion of 1-2 microliters of physiologic buffer into the venous sinus (sinus venosus) followed by topical application of 2 Molar sodium chloride to induce ventricular tetany

Comparator

Baseline

Outcome

Ventricular pressure-volume relations (end-diastolic and end-systolic pressure-volume relations, stroke volume, arterial elastance, pressure-volume loop area)surrogate

Embryonic ventricular pressure-volume relations define diastolic and systolic function at rest and in response to altered preload during cardiovascular development.

Cite This Study

Keller et al. (1994) studied this question.

synapsesocial.com/papers/6a910c6dfae915895c361c9f https://doi.org/10.1017/s1047951100010829

View Full Paper

Ask AI

Bookmark

January 1, 1994Cardiology in the Young

Embryonic ventricular diastolic and systolic pressure-volume relations

View Full Paper

Ask AI

Bookmark

Population

n≥6 stage 16, 18 and 21 white Leghorn chick embryos

Comparison

Infusion of 1-2 microliters of physiologic… vs Baseline

Design

Preclinical

Authors

BKBradley B. KellerCincinnati Children's Hospital Medical Center JTJoseph P. TinneyUniversity of Louisville NHNorman HuUniversity of Utah

Discussion

Member takes

Implication

Defines embryonic ventricular mechanics; leaves open translation to human fetal cardiology.

Structured PICO

Population

n≥6 stage 16, 18 and 21 white Leghorn chick embryos

Intervention

Infusion of 1-2 microliters of physiologic buffer into the venous sinus (sinus venosus) followed by topical application of 2 Molar sodium chloride to induce ventricular tetany

Comparator

Baseline

Outcome

Ventricular pressure-volume relations (end-diastolic and end-systolic pressure-volume relations, stroke volume, arterial elastance, pressure-volume loop area)surrogate

Embryonic ventricular pressure-volume relations define diastolic and systolic function at rest and in response to altered preload during cardiovascular development.

Cite This Study

Keller et al. (1994) studied this question.

synapsesocial.com/papers/6a910c6dfae915895c361c9f https://doi.org/10.1017/s1047951100010829

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark