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January 1, 1991Circulation Research

Ventricular pressure-area loop characteristics in the stage 16 to 24 chick embryo.

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Population

Stage 16 to stage 24 white Leghorn chick embryos, n ≥ 4

Design

Preclinical

Authors

BKBradley B. KellerCincinnati Children's Hospital Medical CenterNHN. HuHarbin UniversityPSPeter SerrinoUniversity of Rochester

Discussion

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Implication

Provides proof-of-concept for pressure-area loops in chick embryos; leaves open translation to mammalian or clinical ventricular assessment.

Structured PICO

P
Population
Stage 16 to stage 24 white Leghorn chick embryos, n ≥ 4
I
Intervention
Simultaneous measurement of ventricular pressure with a servo-null pressure system and video imaging to generate pressure-area loops
O
Outcome
Ventricular function defined by pressure-area loopssurrogate

Pressure-area relations accurately define ventricular function in the embryonic chick heart, providing a feasible alternative to pressure-volume loops.

Cite This Study

Keller et al. (1991) studied this question.

synapsesocial.com/papers/6a702e5331a3df824328746ahttps://doi.org/10.1161/01.res.68.1.226
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Negative Ventricular Diastolic Pressure in Beating Heart Studied in vitro and in vivo.1956 · 35 citations
  2. 2Effect of arterial impedance changes on the end-systolic pressure-volume relation.1984 · 182 citations
  3. 3Input impedance of the systemic circulation in man.1977 · 295 citations
  4. 4Steady and Pulsatile Energy Losses in the Systemic Circulation under Normal Conditions and in Simulated Arterial Disease1967 · 220 citations
  5. 5Valvular action in the embryonic chick heart by localized apposition of endocardial masses1948 · 128 citations