What does this research mean for the field?

High-activity promoter genotypes of the matrix metalloproteinase 9 (MMP9) gene are independently associated with larger complicated coronary atherosclerotic lesion areas in older men. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to investigate the relationship between MMP9 gene polymorphism and the area of complicated coronary lesions.

September 1, 2001Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Coronary Artery Complicated Lesion Area Is Related to Functional Polymorphism of Matrix Metalloproteinase 9 Gene

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Why the study?

Does the MMP9 gene promoter polymorphism affect the area of complicated coronary atherosclerotic lesions in men?

Population

276 men aged 33 to 69 years from an autopsy cohort

Comparison

High-activity MMP9 genotypes (C/T, T/T) vs Low-activity MMP9 genotype (C/C)

Design

Cohort

Authors

PPPerttu J. PöllänenTampere University PKPekka J. KarhunenGeneral / Preventive / Lipids JMJussi MikkelssonHelsinki University Hospital

Discussion

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Implication

May support MMP9 variant role in plaque complexity among older men; hypothesis-generating and requires prospective validation.

Key Points

This research aims to investigate the relationship between MMP9 gene polymorphism and the area of complicated coronary lesions.
Cohort of 276 men aged 33 to 69 years was analyzed for coronary lesions through autopsy measurements.
MMP9 genotypes were determined using polymerase chain reaction and restriction enzyme digestion.
Analysis adjusted for age, body mass index, hypertension, diabetes, and smoking status.
In men aged 53 years and older, larger complicated lesion areas were significantly associated with high-activity MMP9 genotypes (P=0.008).
MMP9 genotype remained an independent predictor of complicated lesion area after adjustments (P=0.012).
Subjects with high promoter activity genotypes typically exhibited more extensive complicated lesions than those with low-activity genotypes.

Structured PICO

Does the MMP9 gene promoter polymorphism affect the area of complicated coronary atherosclerotic lesions in men?

Population

276 men aged 33 to 69 years from an autopsy cohort

Intervention

High-activity MMP9 genotypes (C/T, T/T)

Comparator

Low-activity MMP9 genotype (C/C)

Outcome

Area of complicated coronary atherosclerotic lesionssurrogate

The MMP9 gene promoter polymorphism (-1562 C-to-T) is independently associated with the area of complicated coronary atherosclerotic lesions, suggesting a genetic influence on plaque vulnerability and progression.

Cite This Study

Pöllänen et al. (2001) studied this question.

synapsesocial.com/papers/6a1bc2d601af05bf0da8eafb https://doi.org/10.1161/hq0901.095545

Topics

Coronary artery disease

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Coronary Artery Complicated Lesion Area Is Related to Functional Polymorphism of Matrix Metalloproteinase 9 Gene

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Coronary Artery Complicated Lesion Area Is Related to Functional Polymorphism of Matrix Metalloproteinase 9 Gene

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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