What does this research mean for the field?

Young patients with mild essential hypertension exhibit abnormally high albumin excretion and low renal plasma flow during exercise, which is partially normalized by long-term propranolol therapy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1981Scandinavian Journal of Clinical and Laboratory Investigation

Effects of exercise on urinary excretion of albumin and β₂-microglobulin in young patients with mild essential hypertension without treatment and during long-term propranolol treatment

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Why the study?

Does exercise affect urinary excretion of albumin and renal function in young patients with mild essential hypertension, and does propranolol treatment alter this response?

Population

27 young subjects, comprising 9 untreated patients with mild essential hypertension, 8 patients with mild…

Comparison

Exercise. vs Resting state and normotensive healthy control…

Design

Cross-sectional

Follow-up

Acute (during exercise and control periods)

Authors

EPE. B. PedersenUniversity of Copenhagen CMC. E. MogensenGeneral / Preventive / Lipids JLJ. S. LarsenNovo Nordisk (Denmark)

Discussion

Member takes

Implication

Exercise-induced albuminuria may signal early renal changes in mild hypertension; leaves open propranolol's long-term renoprotective effects.

Structured PICO

Does exercise affect urinary excretion of albumin and renal function in young patients with mild essential hypertension, and does propranolol treatment alter this response?

Population

27 young subjects, comprising 9 untreated patients with mild essential hypertension, 8 patients with mild essential hypertension treated with propranolol, and 10 normotensive healthy control subjects.

Intervention

Exercise (two consecutive periods of 20 min each, with a load of 75 W and 100 W, respectively).

Comparator

Resting state (control period of 40 min) and normotensive healthy control subjects.

Outcome

Urinary excretion of albumin, beta 2-microglobulin, renal plasma flow (RPF), and glomerular filtration rate (GFR).surrogate

Young patients with mild essential hypertension exhibit abnormal exercise-induced albuminuria and reduced renal plasma flow, which is partially normalized by propranolol therapy.

Cite This Study

Pedersen et al. (1981) studied this question.

synapsesocial.com/papers/6a1bc49926cb5670aa9cd74d https://doi.org/10.3109/00365518109090488

Topics

Hypertension management

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Implication

Exercise-induced albuminuria may signal early renal changes in mild hypertension; leaves open propranolol's long-term renoprotective effects.

Effects of exercise on urinary excretion of albumin and β₂-microglobulin in young patients with mild essential hypertension without treatment and during long-term propranolol treatment

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effects of exercise on urinary excretion of albumin and β₂-microglobulin in young patients with mild essential hypertension without treatment and during long-term propranolol treatment

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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