Why the study?
Does conventional antihypertensive treatment reduce albumin and beta 2-microglobulin hyperexcretion in young patients with severe essential hypertension?
Population
7 young patients with newly diagnosed severe essential hypertension, mean age 34.9 years.
Comparison
Conventional antihypertensive treatment vs Untreated baseline state
Design
Case_series
Follow-up
one week
Authors
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Supports pressure-driven proteinuria in severe hypertension; leaves open generalizability beyond this case series.
Does conventional antihypertensive treatment reduce albumin and beta 2-microglobulin hyperexcretion in young patients with severe essential hypertension?
Conventional antihypertensive treatment rapidly reverses albumin and beta 2-microglobulin hyperexcretion in patients with severe essential hypertension, indicating that these renal protein handling abnormalities are largely driven by increased filtration pressure.
Cramer Christensen (1983) studied this question.
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