What does this research mean for the field?

Angiotensin converting enzyme inhibition with captopril, either alone or combined with hydrochlorothiazide, effectively lowers blood pressure while preventing or blunting the adverse metabolic effects on potassium, uric acid, glucose, and cholesterol typically caused by diuretic therapy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1987Clinical and Experimental Hypertension Part A Theory and Practice

Metabolic and Blood Pressure Effects of Angiotensin Converting Enzyme Inhibitors in Mild-to-Moderate American Hypertensives

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Why the study?

Does captopril alone or in combination with hydrochlorothiazide improve blood pressure and metabolic profiles compared to hydrochlorothiazide alone in mild-to-moderate essential hypertensives?

Structured PICO

Does captopril alone or in combination with hydrochlorothiazide improve blood pressure and metabolic profiles compared to hydrochlorothiazide alone in mild-to-moderate essential hypertensives?

Population

n=255 American patients with mild-to-moderate essential hypertension

Intervention

Captopril 25 mg tid alone, or in combination with hydrochlorothiazide 15 mg tid

Comparator

Hydrochlorothiazide 15 mg tid alone

Outcome

Change in blood pressure and metabolic parameters (serum potassium, uric acid, glucose, and cholesterol)surrogate

Captopril effectively lowers blood pressure without the adverse metabolic effects associated with hydrochlorothiazide, and mitigates these adverse effects when used in combination.

Discussion

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Implication

Captopril-hydrochlorothiazide combination yields greater blood pressure reduction without metabolic adverse effects; extends evidence supporting ACE inhibitor addition to thiazides in essential hypertension.

Cite This Study

Myron H. Weinberger (1987) studied this question.

synapsesocial.com/papers/6a1bc61cb33628da419cd60f https://doi.org/10.3109/10641968709164237

Topics

Hypertension management

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Metabolic and Blood Pressure Effects of Angiotensin Converting Enzyme Inhibitors in Mild-to-Moderate American Hypertensives

Structured PICO

Discussion

Implication

Cite This Study

Topics

Metabolic and Blood Pressure Effects of Angiotensin Converting Enzyme Inhibitors in Mild-to-Moderate American Hypertensives

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider