Why the study?
Does sympathetic nerve stimulation and autonomic modulation affect the incidence of ischemia/reperfusion-induced arrhythmias in an open-chest dog model?
Does sympathetic nerve stimulation and autonomic modulation affect the incidence of ischemia/reperfusion-induced arrhythmias in an open-chest dog model?
Sympathetic nervous system activation increases the incidence of ischemia/reperfusion arrhythmias by promoting repolarization shortening, increasing heterogeneity, and inducing afterdepolarizations.
Does not change clinical practice; leaves open autonomic modulation for ischemia-reperfusion arrhythmias in future trials.
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Miyazaki et al. (1997) studied this question.
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