Why the study?
Do antiarrhythmic drugs affect the defibrillation threshold in an open-chest dog model?
Do antiarrhythmic drugs affect the defibrillation threshold in an open-chest dog model?
Certain antiarrhythmic drugs, specifically mexiletine and flecainide, increase defibrillation thresholds, suggesting that monitoring drug concentrations and conduction times may help prevent deterioration of defibrillation efficacy.
Hypothesis-generating in dogs; leaves open whether these drugs affect defibrillation thresholds in patients.
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Murakawa et al. (1993) studied this question.
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