Why the study?
Do class I (flecainide) and class III (dofetilide) antiarrhythmic drugs affect the defibrillation threshold in an open-chest dog model?
Do class I (flecainide) and class III (dofetilide) antiarrhythmic drugs affect the defibrillation threshold in an open-chest dog model?
In a canine model, flecainide increases while dofetilide decreases the defibrillation threshold, suggesting that antiarrhythmic drug effects on DFT should be considered when co-administered in patients with ICDs.
Drug effects on DFT merit consideration with antiarrhythmics in ICD patients; leaves open translation from this canine model.
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Sekiguchi et al. (1996) studied this question.
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