What does this research mean for the field?

Silencing the SERCA2 gene in cardiac myocytes triggers a compensatory remodeling of calcium signaling pathways, characterized by the calcineurin-mediated transcriptional up-regulation of TRP channels and the Na+/Ca2+ exchanger. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 16, 2004Proceedings of the National Academy of SciencesOpen Access

Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) gene silencing and remodeling of the Ca2+ signaling mechanism in cardiac myocytes

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Population

Cultured cardiac myocytes

Design

Preclinical

Authors

MSMalini SethUniversity of Maryland, Baltimore CSCarlota SumbillaUniversity of Maryland, Baltimore SMSusan MullenPlanetary Science Institute

Discussion

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Implication

Animal data link SERCA2 loss to Ca2+ remodeling in myocytes; leaves open relevance to human HF.

Structured PICO

Population

Cultured cardiac myocytes

Intervention

Down-regulation of SERCA2 gene expression via endogenous transcription of small interfering RNA delivered by adenovirus vector

Outcome

Changes in expression of Ca2+ signaling proteins (TRP channels, Na+/Ca2+ exchanger) and related transcriptional factorssurrogate

SERCA2 gene silencing in cardiac myocytes induces compensatory remodeling of Ca2+ signaling pathways via transcriptional crosstalk involving TRP channels and the Na+/Ca2+ exchanger.

Cite This Study

Seth et al. (2004) studied this question.

synapsesocial.com/papers/6a1bccf926cb5670aa9cea67 https://doi.org/10.1073/pnas.0407537101

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Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) gene silencing and remodeling of the Ca2+ signaling mechanism in cardiac myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) gene silencing and remodeling of the Ca2+ signaling mechanism in cardiac myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider