January 1, 1996AJP Cell Physiology
Steady-state twitch Ca2+ fluxes and cytosolic Ca2+ buffering in rabbit ventricular myocytes
Population
indo 1-loaded isolated rabbit ventricular myocytes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Quantifies Ca2+ fluxes in rabbit myocytes; leaves open translation to human HF models.
Structured PICO
P
Population
indo 1-loaded isolated rabbit ventricular myocytes
I
Intervention
whole cell voltage clamp and caffeine application
O
Outcome
Intracellular Ca2+ ([Ca2+]i) transients, transsarcolemmal Ca2+ currents, and cytosolic Ca2+ bufferingsurrogate
This preclinical study quantifies Ca2+ fluxes in rabbit ventricular myocytes, demonstrating active buffering of cytosolic Ca2+ by SR Ca2+ uptake during a twitch.
Cite This Study
Delbridge et al. (1996) studied this question.