Why the study?
Does inhibition of pp60c-src or p21ras prevent G protein-coupled receptor-induced proliferation in rat aortic smooth muscle cells?
Population
Rat aortic smooth muscle cells
Comparison
Electroporation of anti-pp60c-src antibodies or… vs Response to platelet-derived growth factor-BB or…
Design
Preclinical
Authors
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pp60c-src may selectively modulate GPCR-driven VSMC proliferation; hypothesis-generating for vascular disease models pending in vivo confirmation.
Does inhibition of pp60c-src or p21ras prevent G protein-coupled receptor-induced proliferation in rat aortic smooth muscle cells?
The pp60c-src tyrosine kinase is specifically required for vascular smooth muscle cell proliferation induced by G protein-coupled receptors, but not by classic growth factor receptors.
Schieffer et al. (1997) studied this question.
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