Key result
Electroporation of anti-pp60c-src antibody blocked angiotensin II-stimulated Ras activation and Ras-Raf-1 complex formation in rat aortic smooth muscle cells.
The AT1 receptor activates the Ras protein cascade via the tyrosine kinase pp60c-src in vascular smooth muscle cells.
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pp60c-src may mediate AT1-Ras signaling in vascular smooth muscle; leaves open its viability as a therapeutic target.
Schieffer et al. (1996) studied this question. anti-pp60c-src antibody vs. antibodies against c-Yes or c-Fyn was evaluated on Ras activation and Ras-Raf-1 complex formation. Electroporation of anti-pp60c-src antibody blocked angiotensin II-stimulated Ras activation and Ras-Raf-1 complex formation in rat aortic smooth muscle cells.
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