Key result
Angiotensin II stimulation of vascular smooth muscle cells and AT1 receptor-transfected cells resulted in an approximately threefold increase in pp60c-src activity within 1 minute.
Why the study?
Does Angiotensin II activate pp60c-src in vascular smooth muscle cells?
Population
Vascular smooth muscle cells and Chinese hamster ovary cells transfected with the AT1 receptor
Comparison
Angiotensin II stimulation vs Untransfected cells or unstimulated state
Design
Preclinical
Follow-up
1 minute
Authors
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Does not inform clinical practice; leaves open pp60c-src as a mediator in AT1 vascular signaling for mechanistic studies.
Does Angiotensin II activate pp60c-src in vascular smooth muscle cells?
Effect estimate: approximately threefold increase
Angiotensin II rapidly activates pp60c-src in vascular smooth muscle cells, providing insight into the intracellular signaling pathways of the AT1 receptor.
Ishida et al. (1995) studied this question. Angiotensin II vs. Unstimulated cells / untransfected cells was evaluated on pp60c-src activity (approximately threefold increase). Angiotensin II stimulation of vascular smooth muscle cells and AT1 receptor-transfected cells resulted in an approximately threefold increase in pp60c-src activity within 1 minute.
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