Increasing intracellular cAMP inhibits thrombin-induced mitogenesis in vascular smooth muscle cells by suppressing JNK1 activity and c-Jun expression, independent of the ERK pathway.
No takes yet. Share an insight, caveat, or question.
cAMP elevation may inhibit thrombin-driven VSMC mitogenesis via JNK/c-Jun; leaves open relevance to human vascular disease.
Rao et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: