Why the study?
Does JNK1 inhibition reduce thrombus formation and platelet aggregation in vitro and in vivo?
Population
In vitro platelet models, a Glanzmann thrombastenic patient lacking alphaIIbbeta3, and in vivo mouse models…
Design
Preclinical
Authors
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JNK1 inhibition may reduce high-shear arterial thrombosis in mice; leaves open translation to human antithrombotic therapy.
Does JNK1 inhibition reduce thrombus formation and platelet aggregation in vitro and in vivo?
JNK1 plays a novel and critical role in arterial thrombus formation under high shear conditions, suggesting a potential new target for antithrombotic therapy.
Kauskot et al. (2007) studied this question.
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